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Treatments for Prevention and Treatment of Flu in Children

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Flu shot (vaccine)

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Insignificant

Flu prevention in healthy Children

Curefacts.com - Evidence icon EVIDENCE | WELL TESTED - 75 studies with 300,000 children
Curefacts.com - Circle icon EFFECTIVENESS | MILD BENEFITS for prevention of symptoms
Curefacts.com - Circle icon SAFETY | MILD RISKS
Flu shot vaccine with “dead” inactivated viruses. 75 studies conducted, with 300,000 children. Prevents 1 flu case in 28 vaccinated children, and 1 influenza-like-illness in 8 vaccinated children. Doesn't prevent flu complications. irritating side effects. Unclear safety.

Flu Nasal Aerosol (vaccine)

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Mixed

Flu prevention in healthy Children

Curefacts.com - Evidence icon EVIDENCE | WELL TESTED - 75 studies with 300,000 children
Curefacts.com - Circle icon EFFECTIVENESS | EFFECTIVE for prevention of symptoms
Curefacts.com - Circle icon SAFETY | DANGEROUS
Flu nose spray vaccine with “live” (weakened) viruses. 75 studies conducted, with 300,000 children. Prevents 1 flu case in 6 vaccinated children, and 1 influenza-like-illness in 12 vaccinated children. Does not prevent flu complications. Strong side effects. Known serious harms.

Neuraminidase inhibitors (RX)

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Mixed

Flu treatment in Children with Flu

Curefacts.com - Evidence icon EVIDENCE | REASONABLY TESTED - 6 studies with 2,356 children
Curefacts.com - Circle icon EFFECTIVENESS | MILD BENEFITS
Curefacts.com - Circle icon SAFETY | MILD RISKS
Treatment with Neuraminidase inhibitors (e.g. zanamivir, oseltamivir). 6 studies conducted, with 2,356 children. Shortens the duration of the Flu symptoms by 1 day on average, and may reduce ear infections. Impact on other complications remains unclear. Mild side effects, including vomiting.

Neuraminidase inhibitors (RX)

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Mixed

Flu prevention in healthy Children

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 3 studies with 863 children
Curefacts.com - Circle icon EFFECTIVENESS | MILD BENEFITS for prevention of symptoms
Curefacts.com - Circle icon SAFETY | MILD RISKS
Preventive treatment with Neuraminidase inhibitors (e.g. zanamivir, oseltamivir). 3 studies conducted, with 863 children. Prevents 1 case of influenza transmission when given to 12 children in households were a member already has the Flu. Mild side effects, including vomiting.

Amantadine and Rimantadine (RX)

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Mixed

Flu prevention in healthy Children

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 5 studies with 1,007 children
Curefacts.com - Circle icon EFFECTIVENESS | MILD BENEFITS
Curefacts.com - Circle icon SAFETY | DANGEROUS
Prevention of influenza A with Amantadine and Rimantadine. 5 studies conducted, with 1,007 children. Amantadine prevents 5.88% of confirmed flu type A infections during influenza A epidemic outbreaks, while Rimantadine is ineffective. The impact of both on complications is unclear. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

Amantadine and Rimantadine (RX)

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Mixed

Flu treatment in Children with Flu

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 3 studies with 382 children
Curefacts.com - Circle icon EFFECTIVENESS | NEGLIGIBLE BENEFITS for fever
Curefacts.com - Circle icon SAFETY | DANGEROUS
Treatment of Influenza A with Amantadine and Rimantadine. 3 studies conducted, with 382 children. Reduces the fever on the 3rd day of treatment for 1 in 6 treated children, and ineffective for other symptoms. Unknown impact on complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

Flu shot (vaccine)

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Unclear

Flu prevention in Children with Cancer

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 10 studies with 770 children
Curefacts.com - Circle icon EFFECTIVENESS | UNCLEAR
Curefacts.com - Circle icon SAFETY | MILD RISKS
Flu shot vaccine with “dead” inactivated viruses in children with cancer undergoing chemotherapy. 10 studies conducted, with 770 children. Generates a relatively mild immune response during chemotherapy. Prevention of flu symptoms and complications is unknown and was not measured. Mild side effects.

Neuraminidase inhibitors (RX)

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Unclear

Flu treatment in Children with Cystic Fibrosis with Flu

Curefacts.com - Evidence icon EVIDENCE | NOT TESTED
Curefacts.com - Circle icon EFFECTIVENESS | UNCLEAR
Curefacts.com - Circle icon SAFETY | DANGEROUS
Treatment with Neuraminidase inhibitors (e.g. zanamivir, oseltamivir). No studies conducted, and therefore no data exists on benefits. Seems safe for Oseltamivir. Mild known side effects, including vomiting. Zanamivir may evoke asthma attacks and is risky for children with Cystic Fibrosis.

Flu shot (vaccine)

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Unclear

Flu prevention in Children with Cystic Fibrosis

Curefacts.com - Evidence icon EVIDENCE | POORLY TESTED - 4 studies with 143 children
Curefacts.com - Circle icon EFFECTIVENESS | UNCLEAR
Curefacts.com - Circle icon SAFETY | UNCLEAR SAFETY
Flu shot vaccine with “dead” inactivated viruses. 4 studies conducted, with 143 children. Unclear benefits. Irritating side effects and unclear safety.

Flu Nasal Aerosol (vaccine)

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Unclear

Flu prevention in Children with Cystic Fibrosis

Curefacts.com - Evidence icon EVIDENCE | POORLY TESTED - 2 studies with 60 children
Curefacts.com - Circle icon EFFECTIVENESS | UNCLEAR
Curefacts.com - Circle icon SAFETY | DANGEROUS
Flu nose spray vaccine with “live” (weakened) viruses. 2 studies conducted, with 60 children. Unclear benefits. Strong side effects. Known serious harms.

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