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Amantadine and Rimantadine (RX) for Treatment of Flu in Adults With Flu

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Amantadine and Rimantadine (RX)

Mixed

Flu treatment in Adults with Flu

EVIDENCE | REASONABLY TESTED - 13 studies with 1,151 adults

EFFECTIVENESS | MILD BENEFITS for fever

SAFETY | MILD RISKS

Treatment of Influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 13 studies conducted, with 1,151 adults. Shortened the duration of fever by about one day. Unknown impact on complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

Amantadine and Rimantadine (RX)

Unclear

Flu treatment in Adults with Cystic Fibrosis with Flu

EVIDENCE | NOT TESTED

EFFECTIVENESS | UNCLEAR

SAFETY | DANGEROUS

Treatment with Neuraminidase inhibitors (e.g. zanamivir, oseltamivir). No studies conducted, and therefore no data exists on benefits. Seems safe for Oseltamivir. Mild known side effects, including vomiting. Zanamivir may evoke asthma attacks and is risky for adults with Cystic Fibrosis.

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Flu

Amantadine (trade name Symmetrel, by Endo Pharmaceuticals) is a drug that has U.S. Food and Drug Administration approval for use both as an antiviral and an antiparkinsonian drug. Rimantadine (INN, sold under the trade name Flumadine) is an orally administered antiviral drug used to treat, and in rare cases prevent, influenza virus A infection. Both rimantadine and Amantadine are derivates of adamantane. (source)

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