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Treatments (RX) for Prevention and Treatment of Flu in All Ages

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Neuraminidase inhibitors (RX)

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Mixed

Flu treatment in Children with Flu

Curefacts.com - Evidence icon EVIDENCE | REASONABLY TESTED - 6 studies with 2,356 children
Curefacts.com - Circle icon EFFECTIVENESS | MILD BENEFITS
Curefacts.com - Circle icon SAFETY | MILD RISKS
Treatment with Neuraminidase inhibitors (e.g. zanamivir, oseltamivir). 6 studies conducted, with 2,356 children. Shortens the duration of the Flu symptoms by 1 day on average, and may reduce ear infections. Impact on other complications remains unclear. Mild side effects, including vomiting.

Neuraminidase inhibitors (RX)

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Mixed

Flu prevention in healthy Children

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 3 studies with 863 children
Curefacts.com - Circle icon EFFECTIVENESS | MILD BENEFITS for prevention of symptoms
Curefacts.com - Circle icon SAFETY | MILD RISKS
Preventive treatment with Neuraminidase inhibitors (e.g. zanamivir, oseltamivir). 3 studies conducted, with 863 children. Prevents 1 case of influenza transmission when given to 12 children in households were a member already has the Flu. Mild side effects, including vomiting.

Amantadine and Rimantadine (RX)

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Mixed

Flu prevention in healthy Adults

Curefacts.com - Evidence icon EVIDENCE | WELL TESTED - 21 studies with 25,783 adults
Curefacts.com - Circle icon EFFECTIVENESS | MILD BENEFITS
Curefacts.com - Circle icon SAFETY | DANGEROUS
Prevention of influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 21 studies conducted, with 25,783 adults. Prevents 25% of influenza-like-illness in and over 60% of confirmed flu type A infections during influenza A epidemic outbreaks. Unknown impact in flu complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

Amantadine and Rimantadine (RX)

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Mixed

Flu treatment in Adults with Flu

Curefacts.com - Evidence icon EVIDENCE | REASONABLY TESTED - 13 studies with 1,151 adults
Curefacts.com - Circle icon EFFECTIVENESS | MILD BENEFITS for fever
Curefacts.com - Circle icon SAFETY | MILD RISKS
Treatment of Influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 13 studies conducted, with 1,151 adults. Shortened the duration of fever by about one day. Unknown impact on complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

Amantadine and Rimantadine (RX)

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Mixed

Flu prevention in healthy Children

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 5 studies with 1,007 children
Curefacts.com - Circle icon EFFECTIVENESS | MILD BENEFITS
Curefacts.com - Circle icon SAFETY | DANGEROUS
Prevention of influenza A with Amantadine and Rimantadine. 5 studies conducted, with 1,007 children. Amantadine prevents 5.88% of confirmed flu type A infections during influenza A epidemic outbreaks, while Rimantadine is ineffective. The impact of both on complications is unclear. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

Amantadine and Rimantadine (RX)

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Mixed

Flu treatment in Children with Flu

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 3 studies with 382 children
Curefacts.com - Circle icon EFFECTIVENESS | NEGLIGIBLE BENEFITS for fever
Curefacts.com - Circle icon SAFETY | DANGEROUS
Treatment of Influenza A with Amantadine and Rimantadine. 3 studies conducted, with 382 children. Reduces the fever on the 3rd day of treatment for 1 in 6 treated children, and ineffective for other symptoms. Unknown impact on complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

Amantadine and Rimantadine (RX)

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Damaging

Flu prevention in healthy Seniors

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 4 studies with 838 seniors
Curefacts.com - Circle icon EFFECTIVENESS | INEFFECTIVE
Curefacts.com - Circle icon SAFETY | DANGEROUS
Prevention of influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 4 studies conducted, with 838 seniors. Ineffective in prevention of flu type A infections. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

Neuraminidase inhibitors (RX)

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Unclear

Flu treatment in Children with Cystic Fibrosis with Flu

Curefacts.com - Evidence icon EVIDENCE | NOT TESTED
Curefacts.com - Circle icon EFFECTIVENESS | UNCLEAR
Curefacts.com - Circle icon SAFETY | DANGEROUS
Treatment with Neuraminidase inhibitors (e.g. zanamivir, oseltamivir). No studies conducted, and therefore no data exists on benefits. Seems safe for Oseltamivir. Mild known side effects, including vomiting. Zanamivir may evoke asthma attacks and is risky for children with Cystic Fibrosis.

Neuraminidase inhibitors (RX)

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Unclear

Flu treatment in Adults with Cystic Fibrosis with Flu

Curefacts.com - Evidence icon EVIDENCE | NOT TESTED
Curefacts.com - Circle icon EFFECTIVENESS | UNCLEAR
Curefacts.com - Circle icon SAFETY | DANGEROUS
Treatment with Neuraminidase inhibitors (e.g. zanamivir, oseltamivir). No studies conducted, and therefore no data exists on benefits. Seems safe for Oseltamivir. Mild known side effects, including vomiting. Zanamivir may evoke asthma attacks and is risky for adults with Cystic Fibrosis.

Amantadine and Rimantadine (RX)

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Unclear

Flu treatment in Seniors with Flu

Curefacts.com - Evidence icon EVIDENCE | NOT TESTED
Curefacts.com - Circle icon EFFECTIVENESS | UNCLEAR
Curefacts.com - Circle icon SAFETY | DANGEROUS
Treatment of Influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. No valid studies conducted. Therefore, no data exists on benefits. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

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