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Neuraminidase inhibitors for Prevention and Treatment of Flu in All Ages

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Neuraminidase inhibitors (RX)

Mixed

Flu treatment in Children with Flu

EVIDENCE | REASONABLY TESTED - 6 studies with 2,356 children

EFFECTIVENESS | MILD BENEFITS

SAFETY | MILD RISKS

Treatment with Neuraminidase inhibitors (e.g. zanamivir, oseltamivir). 6 studies conducted, with 2,356 children. Shortens the duration of the Flu symptoms by 1 day on average, and may reduce ear infections. Impact on other complications remains unclear. Mild side effects, including vomiting.

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Neuraminidase inhibitors (RX)

Mixed

Flu prevention in healthy Children

EVIDENCE | NEEDS MORE TESTING - 3 studies with 863 children

EFFECTIVENESS | MILD BENEFITS for prevention of symptoms

SAFETY | MILD RISKS

Preventive treatment with Neuraminidase inhibitors (e.g. zanamivir, oseltamivir). 3 studies conducted, with 863 children. Prevents 1 case of influenza transmission when given to 12 children in households were a member already has the Flu. Mild side effects, including vomiting.

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Neuraminidase inhibitors (RX)

Unclear

Flu treatment in Children with Cystic Fibrosis with Flu

EVIDENCE | NOT TESTED

EFFECTIVENESS | UNCLEAR

SAFETY | DANGEROUS

Treatment with Neuraminidase inhibitors (e.g. zanamivir, oseltamivir). No studies conducted, and therefore no data exists on benefits. Seems safe for Oseltamivir. Mild known side effects, including vomiting. Zanamivir may evoke asthma attacks and is risky for children with Cystic Fibrosis.

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Neuraminidase inhibitors (RX)

Unclear

Flu treatment in Adults with Cystic Fibrosis with Flu

EVIDENCE | NOT TESTED

EFFECTIVENESS | UNCLEAR

SAFETY | DANGEROUS

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Neuraminidase inhibitors

Neuraminidase inhibitors (NAIs) are a class of drugs which block the neuraminidase enzyme. They are commonly used as antiviral drugs because they block the function of viral neuraminidases of the influenza virus, by preventing its reproduction by budding from the host cell. Oseltamivir (Tamiflu) a prodrug, Zanamivir (Relenza), Laninamivir (Inavir), and Peramivir belong to this class. (source)

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Neuraminidase inhibitors for Prevention and Treatment of Flu in All Ages

Neuraminidase inhibitors (RX)

Flu treatment in Children with Flu

Neuraminidase inhibitors (RX)

Flu prevention in healthy Children

Neuraminidase inhibitors (RX)

Flu treatment in Children with Cystic Fibrosis with Flu

Neuraminidase inhibitors (RX)

Flu treatment in Adults with Cystic Fibrosis with Flu