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Viregyt

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Amantadine and Rimantadine
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Viregyt for Prevention and Treatment of Flu in All Ages

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Viregyt (RX)

Mixed

Flu prevention in healthy Adults

EVIDENCE | WELL TESTED - 21 studies with 25,783 adults

EFFECTIVENESS | MILD BENEFITS

SAFETY | DANGEROUS

Prevention of influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 21 studies conducted, with 25,783 adults. Prevents 25% of influenza-like-illness in and over 60% of confirmed flu type A infections during influenza A epidemic outbreaks. Unknown impact in flu complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

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Viregyt (RX)

Mixed

Flu treatment in Adults with Flu

EVIDENCE | REASONABLY TESTED - 13 studies with 1,151 adults

EFFECTIVENESS | MILD BENEFITS for fever

SAFETY | MILD RISKS

Treatment of Influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 13 studies conducted, with 1,151 adults. Shortened the duration of fever by about one day. Unknown impact on complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

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Viregyt (RX)

Mixed

Flu prevention in healthy Children

EVIDENCE | NEEDS MORE TESTING - 5 studies with 1,007 children

EFFECTIVENESS | MILD BENEFITS

SAFETY | DANGEROUS

Prevention of influenza A with Amantadine and Rimantadine. 5 studies conducted, with 1,007 children. Amantadine prevents 5.88% of confirmed flu type A infections during influenza A epidemic outbreaks, while Rimantadine is ineffective. The impact of both on complications is unclear. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

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Viregyt (RX)

Mixed

Flu treatment in Children with Flu

EVIDENCE | NEEDS MORE TESTING - 3 studies with 382 children

EFFECTIVENESS | NEGLIGIBLE BENEFITS for fever

SAFETY | DANGEROUS

Treatment of Influenza A with Amantadine and Rimantadine. 3 studies conducted, with 382 children. Reduces the fever on the 3rd day of treatment for 1 in 6 treated children, and ineffective for other symptoms. Unknown impact on complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

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Viregyt (RX)

Damaging

Flu prevention in healthy Seniors

EVIDENCE | NEEDS MORE TESTING - 4 studies with 838 seniors

EFFECTIVENESS | INEFFECTIVE

SAFETY | DANGEROUS

Prevention of influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 4 studies conducted, with 838 seniors. Ineffective in prevention of flu type A infections. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

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Viregyt (RX)

Unclear

Flu treatment in Seniors with Flu

EVIDENCE | NOT TESTED

EFFECTIVENESS | UNCLEAR

SAFETY | DANGEROUS

Treatment of Influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. No valid studies conducted. Therefore, no data exists on benefits. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

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Viregyt

Amantadine (trade name Symmetrel, by Endo Pharmaceuticals) is a drug that has U.S. Food and Drug Administration approval for use both as an antiviral and an antiparkinsonian drug. Rimantadine (INN, sold under the trade name Flumadine) is an orally administered antiviral drug used to treat, and in rare cases prevent, influenza virus A infection. Both rimantadine and Amantadine are derivates of adamantane. (source)

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Viregyt for Prevention and Treatment of Flu in All Ages

Viregyt (RX)

Flu prevention in healthy Adults

Viregyt (RX)

Flu treatment in Adults with Flu

Viregyt (RX)

Flu prevention in healthy Children

Viregyt (RX)

Flu treatment in Children with Flu

Viregyt (RX)

Flu prevention in healthy Seniors

Viregyt (RX)

Flu treatment in Seniors with Flu