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Amantadine hydrochloride for prevention of Influenza infection in All Ages

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Amantadine hydrochloride (RX)

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Mixed

Influenza infection prevention in healthy Adults

Curefacts.com - Evidence icon EVIDENCE | WELL TESTED - 21 studies with 25,783 adults
Curefacts.com - Circle icon EFFECTIVENESS | MILD BENEFITS
Curefacts.com - Circle icon SAFETY | DANGEROUS
Prevention of influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 21 studies conducted, with 25,783 adults. Prevents 25% of influenza-like-illness in and over 60% of confirmed flu type A infections during influenza A epidemic outbreaks. Unknown impact in flu complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

Amantadine hydrochloride (RX)

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Mixed

Influenza infection prevention in healthy Children

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 5 studies with 1,007 children
Curefacts.com - Circle icon EFFECTIVENESS | MILD BENEFITS
Curefacts.com - Circle icon SAFETY | DANGEROUS
Prevention of influenza A with Amantadine and Rimantadine. 5 studies conducted, with 1,007 children. Amantadine prevents 5.88% of confirmed flu type A infections during influenza A epidemic outbreaks, while Rimantadine is ineffective. The impact of both on complications is unclear. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

Amantadine hydrochloride (RX)

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Damaging

Influenza infection prevention in healthy Seniors

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 4 studies with 838 seniors
Curefacts.com - Circle icon EFFECTIVENESS | INEFFECTIVE
Curefacts.com - Circle icon SAFETY | DANGEROUS
Prevention of influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 4 studies conducted, with 838 seniors. Ineffective in prevention of flu type A infections. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

Additional Information

Amantadine hydrochloride

Amantadine (trade name Symmetrel, by Endo Pharmaceuticals) is a drug that has U.S. Food and Drug Administration approval for use both as an antiviral and an antiparkinsonian drug. Rimantadine (INN, sold under the trade name Flumadine) is an orally administered antiviral drug used to treat, and in rare cases prevent, influenza virus A infection. Both rimantadine and Amantadine are derivates of adamantane. (source)

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