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  • Antihistamine, analgesic and decongestant combination
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Treatments (OTC) for Treatment of a cold in Adults

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Antihistamine and analgesic combination (OTC)

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Helpful

a cold treatment in Adults with cold

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 3 studies with 1,508 adults
Curefacts.com - Circle icon EFFECTIVENESS | EFFECTIVE for fever, general discomfort, pains and sneezing
Curefacts.com - Circle icon SAFETY | PROBABLY SAFE
Treatment with Antihistamine and Analgesic OTC combination. 3 valid studies conducted, with 1,508 participants. Reduces fever, pain and perhaps sneezing, and improves general feeling (but does not seem to reduce cough, runny nose, and stuffy nose). Side effects seem minor, when sticking to recommended dosage.

Analgesic and decongestant combination (OTC)

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Helpful

a cold treatment in Adults with cold

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 5 studies with 1,627 adults
Curefacts.com - Circle icon EFFECTIVENESS | EFFECTIVE for fever, general discomfort, pains and stuffy nose
Curefacts.com - Circle icon SAFETY | MILD RISKS
Treatment with analgesic and decongestant combination (e.g. ibuprofen and pseudoephedrine). 5 valid studies conducted, with 1,627 participants. Improves general feeling and reduces fever, pain, and blockage of the nose. Side effects seem minor, including dizziness that is relatively frequent.

Antihistamine, analgesic and decongestant combination (OTC)

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Helpful

a cold treatment in Adults with cold

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 4 studies with 760 adults
Curefacts.com - Circle icon EFFECTIVENESS | EFFECTIVE for fever, general discomfort, pains, runny nose and stuffy nose
Curefacts.com - Circle icon SAFETY | MILD RISKS
Treatment with antihistamine, analgesic and decongestant combination (e.g. Acetaminophen, Chlorpheniramine and Pseudoephedrine). 4 valid studies conducted, with 760 adults. Improves general feeling and reduces fever, pain, and cough. May slightly reduces runny nose and stuffy nose. Seems safe.

Antihistamine and decongestant combination (OTC)

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Insignificant

a cold treatment in Adults with cold

Curefacts.com - Evidence icon EVIDENCE | REASONABLY TESTED - 12 studies with 1,239 adults
Curefacts.com - Circle icon EFFECTIVENESS | MILD BENEFITS for cough, general discomfort, runny nose, sneezing and stuffy nose
Curefacts.com - Circle icon SAFETY | PROBABLY SAFE
Treatment with antihistamine and decongestant combination (e.g. triprolidine and pseudoephedrine). 12 valid studies conducted, with 1,239 individuals. Improves general feeling and may slightly reduce sneezing, cough, runny nose and stuffy nose . Side effects seem minor, and include dry mouth, insomnia and constipation.

NSAIDs (OTC)

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Mixed

a cold treatment in Adults with cold

Curefacts.com - Evidence icon EVIDENCE | REASONABLY TESTED - 9 studies with 1,069 adults
Curefacts.com - Circle icon EFFECTIVENESS | EFFECTIVE for fever, pains and sneezing
Curefacts.com - Circle icon SAFETY | DANGEROUS
Treatment with NSAIDs (e.g. Aspirin, Ibuprofen). 9 valid studies conducted, with 1,069 individuals. Reduces fever, pain and sneezing (but does not seem to reduce cough and runny nose) . Side effects seem minor, but long periods of usage may increase chances to heart attacks and strokes.

Corticosteroids nasal spray (OTC)

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Ineffective

a cold treatment in Adults with cold

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 2 studies with 253 adults
Curefacts.com - Circle icon EFFECTIVENESS | INEFFECTIVE
Curefacts.com - Circle icon SAFETY | MILD RISKS
Treatment with Corticosteroids nose spray. 2 valid study conducted, with 253 adults. Does not relief Common Cold symptoms or their duration. Seems safe.

Paracetamol (OTC)

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Unclear

a cold treatment in Adults with cold

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 4 studies with 758 adults
Curefacts.com - Circle icon EFFECTIVENESS | UNCLEAR
Curefacts.com - Circle icon SAFETY | MILD RISKS
Treatment with Paracetamol. 4 valid studies conducted, with 758 adults. Unclear impact. May relieve runny and stuffy nose, and does not relief sneezing and coughing. Side effects seem minor as long as you avoid overdose.

Additional Information

a cold

Common cold, also known simply as a cold, is a viral infectious disease of the upper respiratory tract that primarily affects the nose. The throat, sinuses, and voice box may also be affected. Signs and symptoms may begin less than two days following exposure. They include coughing, sore throat, runny nose, sneezing, headache, and fever. People usually recover in seven to ten days. Some symptoms may last up to three weeks. In those with other health problems, pneumonia may occasionally develop. (source)

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