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Amantadine hydrochloride for Treatment of seasonal influenza in All Ages

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Amantadine hydrochloride (RX)

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Mixed

seasonal influenza treatment in Adults with Flu

Curefacts.com - Evidence icon EVIDENCE | REASONABLY TESTED - 13 studies with 1,151 adults
Curefacts.com - Circle icon EFFECTIVENESS | MILD BENEFITS for fever
Curefacts.com - Circle icon SAFETY | MILD RISKS
Treatment of Influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 13 studies conducted, with 1,151 adults. Shortened the duration of fever by about one day. Unknown impact on complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

Amantadine hydrochloride (RX)

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Mixed

seasonal influenza treatment in Children with Flu

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 3 studies with 382 children
Curefacts.com - Circle icon EFFECTIVENESS | NEGLIGIBLE BENEFITS for fever
Curefacts.com - Circle icon SAFETY | DANGEROUS
Treatment of Influenza A with Amantadine and Rimantadine. 3 studies conducted, with 382 children. Reduces the fever on the 3rd day of treatment for 1 in 6 treated children, and ineffective for other symptoms. Unknown impact on complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

Amantadine hydrochloride (RX)

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Unclear

seasonal influenza treatment in Seniors with Flu

Curefacts.com - Evidence icon EVIDENCE | NOT TESTED
Curefacts.com - Circle icon EFFECTIVENESS | UNCLEAR
Curefacts.com - Circle icon SAFETY | DANGEROUS
Treatment of Influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. No valid studies conducted. Therefore, no data exists on benefits. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

Additional Information

Amantadine hydrochloride

Amantadine (trade name Symmetrel, by Endo Pharmaceuticals) is a drug that has U.S. Food and Drug Administration approval for use both as an antiviral and an antiparkinsonian drug. Rimantadine (INN, sold under the trade name Flumadine) is an orally administered antiviral drug used to treat, and in rare cases prevent, influenza virus A infection. Both rimantadine and Amantadine are derivates of adamantane. (source)

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