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Treatments for Prevention and Treatment of fever in All Ages

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NSAIDs (OTC)

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Helpful

treatment in Children with cold

Curefacts.com - Evidence icon EVIDENCE | REASONABLY TESTED - 9 studies with 1,069 children
Curefacts.com - Circle icon EFFECTIVENESS | EFFECTIVE for fever, pains and sneezing
Curefacts.com - Circle icon SAFETY | MILD RISKS
Treatment with NSAIDs (e.g. Aspirin, Ibuprofen). 9 valid studies conducted, with 1,069 individuals. Reduces fever, pain and sneezing (but does not seem to reduce cough and runny nose) . Side effects seem minor for children.

Antihistamine and analgesic combination (OTC)

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Helpful

treatment in Children with cold

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 3 studies with 1,508 children
Curefacts.com - Circle icon EFFECTIVENESS | EFFECTIVE for fever, general discomfort, pains and sneezing
Curefacts.com - Circle icon SAFETY | PROBABLY SAFE
Treatment with Antihistamine and Analgesic OTC combination. 3 valid studies conducted, with 1,508 participants. It reduces fever, pain and perhaps sneezing, and improves general feeling (but does not seem to reduce cough, runny nose, and stuffy nose) . Side effects seem minor, but the treatment is very dangerous when not sticking to permitted age and dosage.

Antihistamine and analgesic combination (OTC)

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Helpful

treatment in Adults with cold

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 3 studies with 1,508 adults
Curefacts.com - Circle icon EFFECTIVENESS | EFFECTIVE for fever, general discomfort, pains and sneezing
Curefacts.com - Circle icon SAFETY | PROBABLY SAFE
Treatment with Antihistamine and Analgesic OTC combination. 3 valid studies conducted, with 1,508 participants. Reduces fever, pain and perhaps sneezing, and improves general feeling (but does not seem to reduce cough, runny nose, and stuffy nose). Side effects seem minor, when sticking to recommended dosage.

Analgesic and decongestant combination (OTC)

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Helpful

treatment in Children with cold

Curefacts.com - Evidence icon EVIDENCE | POORLY TESTED - 1 study with 65 children
Curefacts.com - Circle icon EFFECTIVENESS | EFFECTIVE for fever, general discomfort, pains and stuffy nose
Curefacts.com - Circle icon SAFETY | MILD RISKS
Treatment with analgesic and decongestant combination (e.g. ibuprofen and pseudoephedrine). Only 1 valid clinical trial conducted, with 65 children. Improves general feeling and Reduces fever, pain, and blockage of the nose. Side effects seem minor, including dizziness that is relatively frequent.

Analgesic and decongestant combination (OTC)

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Helpful

treatment in Adults with cold

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 5 studies with 1,627 adults
Curefacts.com - Circle icon EFFECTIVENESS | EFFECTIVE for fever, general discomfort, pains and stuffy nose
Curefacts.com - Circle icon SAFETY | MILD RISKS
Treatment with analgesic and decongestant combination (e.g. ibuprofen and pseudoephedrine). 5 valid studies conducted, with 1,627 participants. Improves general feeling and reduces fever, pain, and blockage of the nose. Side effects seem minor, including dizziness that is relatively frequent.

Antihistamine, analgesic and decongestant combination (OTC)

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Helpful

treatment in Adults with cold

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 4 studies with 760 adults
Curefacts.com - Circle icon EFFECTIVENESS | EFFECTIVE for fever, general discomfort, pains, runny nose and stuffy nose
Curefacts.com - Circle icon SAFETY | MILD RISKS
Treatment with antihistamine, analgesic and decongestant combination (e.g. Acetaminophen, Chlorpheniramine and Pseudoephedrine). 4 valid studies conducted, with 760 adults. Improves general feeling and reduces fever, pain, and cough. May slightly reduces runny nose and stuffy nose. Seems safe.

NSAIDs (OTC)

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Mixed

treatment in Adults with cold

Curefacts.com - Evidence icon EVIDENCE | REASONABLY TESTED - 9 studies with 1,069 adults
Curefacts.com - Circle icon EFFECTIVENESS | EFFECTIVE for fever, pains and sneezing
Curefacts.com - Circle icon SAFETY | DANGEROUS
Treatment with NSAIDs (e.g. Aspirin, Ibuprofen). 9 valid studies conducted, with 1,069 individuals. Reduces fever, pain and sneezing (but does not seem to reduce cough and runny nose) . Side effects seem minor, but long periods of usage may increase chances to heart attacks and strokes.

Antihistamine, analgesic and decongestant combination (OTC)

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Mixed

treatment in Children with cold

Curefacts.com - Evidence icon EVIDENCE | POORLY TESTED - 1 study with 201 children
Curefacts.com - Circle icon EFFECTIVENESS | EFFECTIVE for fever and pains
Curefacts.com - Circle icon SAFETY | MILD RISKS
Treatment with antihistamine, analgesic and decongestant combination (e.g. Acetaminophen, Chlorpheniramine and Pseudoephedrine). Only 1 valid study conducted, with 201 children. Ineffective and unsafe for younger children. Seems safe, but no better than regular analgesic (e.g. Acetaminophen) for older children.

Amantadine and Rimantadine (RX)

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Mixed

treatment in Adults with Flu

Curefacts.com - Evidence icon EVIDENCE | REASONABLY TESTED - 13 studies with 1,151 adults
Curefacts.com - Circle icon EFFECTIVENESS | MILD BENEFITS for fever
Curefacts.com - Circle icon SAFETY | MILD RISKS
Treatment of Influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 13 studies conducted, with 1,151 adults. Shortened the duration of fever by about one day. Unknown impact on complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

Amantadine and Rimantadine (RX)

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Mixed

treatment in Children with Flu

Curefacts.com - Evidence icon EVIDENCE | NEEDS MORE TESTING - 3 studies with 382 children
Curefacts.com - Circle icon EFFECTIVENESS | NEGLIGIBLE BENEFITS for fever
Curefacts.com - Circle icon SAFETY | DANGEROUS
Treatment of Influenza A with Amantadine and Rimantadine. 3 studies conducted, with 382 children. Reduces the fever on the 3rd day of treatment for 1 in 6 treated children, and ineffective for other symptoms. Unknown impact on complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

NSAIDs (OTC)

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Damaging

treatment in Seniors with cold

Curefacts.com - Evidence icon EVIDENCE | REASONABLY TESTED - 9 studies with 1,069 seniors
Curefacts.com - Circle icon EFFECTIVENESS | EFFECTIVE for fever, pains and sneezing
Curefacts.com - Circle icon SAFETY | DANGEROUS
Treatment with NSAIDs (e.g. Aspirin, Ibuprofen). 9 valid studies conducted, with 1,069 individuals. Reduces fever, pain and sneezing (but does not seem to reduce cough and runny nose) . Side effects seem dangerous to seniors, including inner gastrointestinal bleeding and other serious bleeding events, and increased chances to peptic ulcers, kidney failure, heart attacks and strokes.

Additional Information

fever

Fever, also known as pyrexia and febrile response, is defined as having a temperature above the normal range due to an increase in the body's temperature set-point. There is not a single agreed-upon upper limit for normal temperature with sources using values between 37.5 and 38.3 °C (99.5 and 100.9 °F). The increase in set-point triggers increased muscle contractions and causes a feeling of cold. This results in greater heat production and efforts to conserve heat. When the set-point temperature returns to normal, a person feels hot, becomes flushed, and may begin to sweat. Rarely a fever may trigger a febrile seizure. This is more common in young children. Fevers do not typically go higher than 41 to 42 °C (105.8 to 107.6 °F). A fever can be caused by many medical conditions ranging from not serious to potentially serious. This includes viral, bacterial and parasitic infections such as the common cold, urinary tract infections, meningitis, malaria and appendicitis among others. Non-infectious causes include vasculitis, deep vein thrombosis, side effects of medication, and cancer among others. It differs from hyperthermia, in that hyperthermia is an increase in body temperature over the temperature set-point, due to either too much heat production or not enough heat loss. (source)

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