Insignificant
Bottom Line
Treatment with antihistamine and decongestant combination (e.g. triprolidine and pseudoephedrine). 12 valid studies conducted, with 1,239 adults and children. Improves general feeling and may slightly reduce sneezing, cough, runny nose and stuffy nose . Side effects seem minor, and include dry mouth and insomnia.
EVIDENCE | REASONABLY TESTED
EFFECTIVENESS | MILD BENEFITS for cough, general discomfort, runny nose, sneezing and stuffy nose
SAFETY | PROBABLY SAFE
Look for alternatives to this treatment:
It has very little measurable impact, and usually brings only temporary and quite insignificant relief. Side effects seem minor.
Note that while infections with various strains of Corona viruses are responsible for most cases of common cold, the new corona virus strain, SARS-CoV-2, leads to an entirely different coronavirus infectious disease, COVID-19. The research of treatments for COVID-19 is still pre mature and not based on solid evidence. Therefore, at this stage, we can only speculate that effective treatments for common cold (and related Corona virus strains) may prove effective for Corona disease 2019 (COVID-19) and the related SARS-CoV-2 strain. Please don't count on it.
For example: a combination of Triprolidine and Pseudoephedrine
Target Population:
Children with cold, 2 to 16 years old
Dosage:
Varies according to combination, age and weight.
Goal:
Treatment of Common Cold symptoms
Reasonably tested
Children Tested
Benefits:
Improves general feeling and may slightly reduce sneezing, cough, runny nose and blockage of the nose. Ineffective for children younger than 5 years old.
Probably safe
Risks:
Minor reported side effects include dry mouth and insomnia.
Medical problem:
Common Cold (symptoms caused by viral infection of the upper respiratory system).
Symptoms and signs:
Cough, general discomfort, headache, runny nose, sneezing, sore throat, stuffy nose and weakness.
Complications:
Bacterial infections: lung infection, middle ear infection, strep throat, sinus infection.
Antihistamine and decongestant combination (OTC)
Additional Information
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Antihistamine and decongestant combination
Antihistamines are drugs which treat allergic rhinitis and other allergies. As an alternative to taking an antihistamine, people who suffer from allergies can instead avoid the substance which irritates them. Antihistamines are usually for short-term treatment. A decongestants, or nasal decongestant, is a type of pharmaceutical drug that is used to relieve nasal congestion in the upper respiratory tract. The active ingredient in most decongestants is either pseudoephedrine or phenylephrine. (source)
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