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Antihistamine and decongestant combination
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Antihistamine and decongestant combination (OTC) for treatment of Common Cold in Children with cold

  • Insignificant

    Bottom Line

  • Treatment with antihistamine and decongestant combination (e.g. triprolidine and pseudoephedrine). 12 valid studies conducted, with 1,239 adults and children. Improves general feeling and may slightly reduce sneezing, cough, runny nose and stuffy nose . Side effects seem minor, and include dry mouth and insomnia.

    • EVIDENCE | REASONABLY TESTED
    • EFFECTIVENESS | MILD BENEFITS for cough, general discomfort, runny nose, sneezing and stuffy nose
    • SAFETY | PROBABLY SAFE

Recommendations

Look for alternatives to this treatment:

It has very little measurable impact, and usually brings only temporary and quite insignificant relief. Side effects seem minor.

About Antihistamine and decongestant combination (OTC)

For example: a combination of Triprolidine and Pseudoephedrine

  • Target Population:

    Children with cold, 2 to 16 years old

  • Dosage:

    Varies according to combination, age and weight.

  • Goal:

    Treatment of Common Cold symptoms

Research Summary

  • Reasonably tested
  • 12 Clinical Studies
  • 1,239 Children Tested
  • Mild benefits

  • Benefits:

    Improves general feeling and may slightly reduce sneezing, cough, runny nose and blockage of the nose. Ineffective for children younger than 5 years old.

  • Probably safe

  • Risks:

    Minor reported side effects include dry mouth and insomnia.

Common Cold Overview

  • Medical problem:

    Common Cold (symptoms caused by viral infection of the upper respiratory system).

  • Symptoms and signs:

    Cough, general discomfort, headache, runny nose, sneezing, sore throat, stuffy nose and weakness.

  • Complications:

    Bacterial infections: lung infection, middle ear infection, strep throat, sinus infection.

Brand Names

Antihistamine and decongestant combination (OTC)

  • Alavert
  • Allerfrim
  • Allerphed
  • Altafed
  • Aphedrid
  • A-Phedrin
  • Aprodine
  • Biofed-PE
  • Claritin-D
  • Conex
  • Drixoral
  • Genac
  • Histafed
  • Hist-PSE
  • Loratadine-D
  • Pediatex TD
  • Trip-PSE
  • Vi-Sudo
  • Zymine-D

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Antihistamines are drugs which treat allergic rhinitis and other allergies. As an alternative to taking an antihistamine, people who suffer from allergies can instead avoid the substance which irritates them. Antihistamines are usually for short-term treatment. A decongestants, or nasal decongestant, is a type of pharmaceutical drug that is used to relieve nasal congestion in the upper respiratory tract. The active ingredient in most decongestants is either pseudoephedrine or phenylephrine. (source)
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