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Antihistamine and decongestant combination
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Antihistamine and decongestant combination (OTC) for treatment of Common Cold in Adults with cold

  • Insignificant

    Bottom Line

  • Treatment with antihistamine and decongestant combination (e.g. triprolidine and pseudoephedrine). 12 valid studies conducted, with 1,239 individuals. Improves general feeling and may slightly reduce sneezing, cough, runny nose and stuffy nose . Side effects seem minor, and include dry mouth, insomnia and constipation.

    • EVIDENCE | REASONABLY TESTED
    • EFFECTIVENESS | MILD BENEFITS for cough, general discomfort, runny nose, sneezing and stuffy nose
    • SAFETY | PROBABLY SAFE

Recommendations

Do not use this treatment:

It has very little measurable impact, and usually brings only temporary and quite insignificant relief. Side effects seem minor.

Doctors Say That

If you suffer from high blood pressure avoid this treatment: decongestants can increase your blood pressure even further, and put you at risk.

About Antihistamine and decongestant combination (OTC)

For example: a combination of Triprolidine and Pseudoephedrine

  • Target Population:

    Adults with cold, 16 to 65 years old

  • Dosage:

    Varies according to combination.

  • Goal:

    Treatment of Common Cold symptoms

Research Summary

  • Reasonably tested
  • 12 Clinical Studies
  • 1,239 Adults Tested
  • Mild benefits
  • Benefits:

    Improves general feeling and may slightly reduce sneezing, cough, runny nose and blockage of the nose.

  • Probably safe
  • Risks:

    Minor reported side effects include dry mouth, insomnia and constipation. Decongestants may increase blood pressure.

Common Cold Overview

  • Medical problem:

    Common Cold (symptoms caused by viral infection of the upper respiratory system).

  • Symptoms and signs:

    Cough, general discomfort, headache, runny nose, sneezing, sore throat, stuffy nose and weakness.

  • Complications:

    Bacterial infections: lung infection, middle ear infection, strep throat, sinus infection.

Brand Names

Antihistamine and decongestant combination (OTC)

  • Alavert
  • Allerfrim
  • Allerphed
  • Altafed
  • Aphedrid
  • A-Phedrin
  • Aprodine
  • Biofed-PE
  • Claritin-D
  • Conex
  • Drixoral
  • Genac
  • Histafed
  • Hist-PSE
  • Loratadine-D
  • Pediatex TD
  • Trip-PSE
  • Vi-Sudo
  • Zymine-D

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Antihistamines are drugs which treat allergic rhinitis and other allergies. As an alternative to taking an antihistamine, people who suffer from allergies can instead avoid the substance which irritates them. Antihistamines are usually for short-term treatment. A decongestants, or nasal decongestant, is a type of pharmaceutical drug that is used to relieve nasal congestion in the upper respiratory tract. The active ingredient in most decongestants is either pseudoephedrine or phenylephrine. (source)
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