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Antihistamine and analgesic combination
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Antihistamine and analgesic combination (OTC) for treatment of Common Cold in Adults with cold

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    Bottom Line

  • Treatment with Antihistamine and Analgesic OTC combination. 3 valid studies conducted, with 1,508 participants. Reduces fever, pain and perhaps sneezing, and improves general feeling (but does not seem to reduce cough, runny nose, and stuffy nose). Side effects seem minor, when sticking to recommended dosage.

    • EFFECTIVENESS | EFFECTIVE for fever, general discomfort, pains and sneezing


Consider this treatment with caution, and only when sneezing:

Analgesics improve general feeling and reliefs discomfort caused by a cold (fever, pain). Antihistamines may slightly relief sneezing. Do not expect this treatment to reduce cough, stuffy nose and runny nose or to speed up recovery. Side effects seem minor. All in all - in most cases you'd better use only Paracetamol instead.

Doctors Say That

You should prefer combinations with Paracetamol, since they are safer than combinations with NSAIDs (e.g. Advil) . Using NSAIDs can cause severe damage, especially to adults with gastric-intestinal infections or hidden kidney disease, which are quite common.

About Antihistamine and analgesic combination (OTC)

For example: Diphenhydramine Hydrochloride and Acetaminophen combination

  • Target Population:

    Adults with cold, 16 to 65 years old

  • Dosage:

    Varies according to combination. Stick to the directions on the package or as prescribed by your doctor.

  • Goal:

    Treatment of Common Cold symptoms

Research Summary

  • Needs more testing
  • 3 Clinical Studies
  • 1,508 Adults Tested
  • Effective
  • Benefits:

    Reduces fever and pain and improves general feeling. May slightly reduce sneezing. Does not seem to improve cough, runny nose and stuffy nose.

  • Probably safe
  • Risks:

    Minor reported side effects vary according to combination (for example - dry mouth, drowsiness, constipation, nausea).

Common Cold Overview

  • Medical problem:

    Common Cold (symptoms caused by viral infection of the upper respiratory system).

  • Symptoms and signs:

    Cough, general discomfort, headache, runny nose, sneezing, sore throat, stuffy nose and weakness.

  • Complications:

    Bacterial infections: lung infection, middle ear infection, strep throat, sinus infection.

Brand Names

Antihistamine and analgesic combination (OTC)

  • Aceta-Gesic
  • Bayer Select Max Strength Night Time Pain
  • Benylin
  • Coricidin Night Time Cold Relief
  • Excedrin PM
  • Excedrin PM Caplet
  • Genapap PM
  • Grippostad
  • Headache Relief PM
  • Legatrin PM
  • Mapap PM
  • Midol PM
  • Night Time Pain
  • Pain Relief PM Extra Strength
  • Percogesic Extra Strength
  • Tylenol Cold Relief Nighttime
  • Tylenol Extra Strength PM
  • Tylenol PM
  • Tylenol Sore Throat Nighttime
  • Unisom with Pain Relief

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Antihistamines are drugs which treat allergic rhinitis and other allergies. As an alternative to taking an antihistamine, people who suffer from allergies can instead avoid the substance which irritates them. Antihistamines are usually for short-term treatment. An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain. Analgesic drugs act in various ways on the peripheral and central nervous systems. Analgesics include paracetamol (known in North America as acetaminophen or simply APAP), the nonsteroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, and opioid drugs such as morphine and oxycodone. (source)
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