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High Dose Flu shot (vaccine) for prevention of Flu in healthy Seniors

  • Insignificant

    Bottom Line

  • Flu shot vaccine with high-dose “dead” inactivated viruses. 7 studies conducted, with 41,141 adults. Prevents 1 additional flu case in 200 high-dose vaccinated seniors when compared to regular dose vaccines. Prevention of complications is unclear. irritating side effects. Unclear safety.

    • EVIDENCE | REASONABLY TESTED
    • EFFECTIVENESS | MILD BENEFITS
    • SAFETY | MILD RISKS

Recommendations

Consider this treatment:

It seems better than regular dose vaccination for seniors, but it is unclear if it prevents complications.

Doctors Say That

Providing high-dose vaccines for seniors makes sense, since seniors have a weaker immune system and a lower antibody response to vaccines.

Note that the information here relates only to HEALTHY seniors. Flu vaccines are, for example, essential for asthmatic seniors.

About High Dose Flu shot (vaccine)

Flu shot vaccine with high dose “dead” inactivated viruses

  • Target Population:

    healthy Seniors, 65 year old and above

  • Dosage:

    Seasonal vaccine (once a year). 0.5 mL (with 60 μg of each vaccine antigen - four times the regular amount). One dose.

  • Goal:

    Prevention of Influenza infection, symptoms and complications.

Research Summary

  • Reasonably tested
  • 7 Clinical Studies
  • 41,141 Seniors Tested
  • Mild benefits
  • Benefits:

    Prevents 1 case of influenza infection when the high-dose vaccine instead of regular vaccine is given to 200 seniors. Does not necessarily prevent complications.

  • Mild risks
  • Risks:

    Unclear. More research needed. Irritating side effects: soreness, redness, and/or swelling from the shot; headache, fever, cough, nausea, muscle aches, itching, sore eyes.

Influenza virus infection Overview

  • Medical problem:

    Flu (influenza virus infection and symptoms).

  • Symptoms and signs:

    Cough, dizziness, fever, headache, nausea, pains, runny nose, sore throat, vomiting and aches.

  • Complications:

    Ear infection, lung infection, Seizures.

Brand Names

High Dose Flu shot (vaccine)

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Influenza vaccines, also known as flu shots or flu jabs, are vaccines that protect against infection by influenza virus. A new version of the vaccine is developed twice a year as the influenza virus rapidly changes. Their effectiveness varies from year to year. The effectiveness in those under two years old and over 65 years old is unknown due to the low quality of the research. There is a high-dose flu vaccine specifically formulated to provide a stronger immune response.Available evidence indicates that vaccinating the elderly with the high-dose vaccine leads to a stronger immune response against influenza than the regular-dose vaccine. (source)
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