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Neuraminidase inhibitors
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Neuraminidase inhibitors (RX) for treatment of Flu in Children with Flu

  • Mixed

    Bottom Line

  • Treatment with Neuraminidase inhibitors (e.g. zanamivir, oseltamivir). 6 studies conducted, with 2,356 children. Shortens the duration of the Flu symptoms by 1 day on average, and may reduce ear infections. Impact on other complications remains unclear. Mild side effects, including vomiting.

    • EVIDENCE | REASONABLY TESTED
    • EFFECTIVENESS | MILD BENEFITS
    • SAFETY | MILD RISKS

Recommendations

Consider this treatment for children with Flu:

It may shorten the duration of the Flu symptoms a bit and prevent ear infections, but it evokes vomiting.

Doctors Say That

Works best if taken within 2 days of having flu symptoms, and should be taken for 5 consecutive days.

About Neuraminidase inhibitors (RX)

For example: Oseltamivir (Tamiflu), Zanamivir (Relenza)

  • Target Population:

    Children with Flu, 2 to 16 years old

  • Dosage:

    Varies according to age, weight and treatment. Oseltamivir usually 2 mg/kg, twice-daily, for 5 days. Zanamivir usually 10 mg, twice-daily, for 5 days.

  • Goal:

    Treatment of Influenza infection, symptoms and complications

Research Summary

  • Reasonably tested
  • 6 Clinical Studies
  • 2,356 Children Tested
  • Mild benefits
  • Benefits:

    Shortened the duration of Flu symptoms by about one day. May reduce ear infections based on only one trial. Unclear impact on other complications.

  • Mild risks
  • Risks:

    Common side effects include vomiting, diarrhea, nausea, headache, nosebleeds and trouble sleeping. Rare side effects may include psychiatric symptoms, trouble breathing and seizures.

Influenza virus infection Overview

  • Medical problem:

    Flu (influenza virus infection and symptoms).

  • Symptoms and signs:

    Cough, dizziness, fever, headache, nausea, pains, runny nose, sore throat, vomiting and aches.

  • Complications:

    Ear infection, lung infection, Seizures.

Other Treatments

Brand Names

Neuraminidase inhibitors (RX)

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Neuraminidase inhibitors (NAIs) are a class of drugs which block the neuraminidase enzyme. They are commonly used as antiviral drugs because they block the function of viral neuraminidases of the influenza virus, by preventing its reproduction by budding from the host cell. Oseltamivir (Tamiflu) a prodrug, Zanamivir (Relenza), Laninamivir (Inavir), and Peramivir belong to this class. (source)
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