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Neuraminidase inhibitors (RX) for prevention of Flu in healthy Children

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    Mixed

    Bottom Line

  • Preventive treatment with Neuraminidase inhibitors (e.g. zanamivir, oseltamivir). 3 studies conducted, with 863 children. Prevents 1 case of influenza transmission when given to 12 children in households were a member already has the Flu. Mild side effects, including vomiting.

    • Curefacts.com -  Evidence icon EVIDENCE | NEEDS MORE TESTING
    • Curefacts.com -  Effectiveness icon EFFECTIVENESS | MILD BENEFITS
    • Curefacts.com -  Safety Circle icon SAFETY | MILD RISKS

Recommendations

If a household member has the flu, consider this treatment:

It prevents 8% of flu transmissions, but may evoke vomiting.

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Works best if taken within 2 days of being exposed to the flu, and should be taken for 10 consecutive days.

About Neuraminidase inhibitors (RX)

For example: Oseltamivir (Tamiflu), Zanamivir (Relenza)

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    Target Population:

    healthy Children, 2 to 16 years old

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    Dosage:

    Varies according to age, weight and treatment. Oseltamivir usually up to 75 mg, twice-daily, for 5 days. Zanamivir usually up to 30 mg, twice-daily, for 10 days.

  • Curefacts.com - Goal icon

    Goal:

    Prevention of Influenza infection, symptoms and complications

Research Summary

  • Curefacts.com - Green Pages icon Needs more testing
  • 3 Clinical Studies
  • 863 Curefacts.com - Tooltip icon Children Tested
  • Mild benefits
  • Benefits:

    In households were a member already has the Flu, it prevents 1 case of influenza transmission and flu symptoms when the treatment is given to 12 children.

  • Curefacts.com - Safety icon Mild risks
  • Risks:

    Common side effects include vomiting, diarrhea, nausea, headache, nosebleeds and trouble sleeping. Rare side effects may include psychiatric symptoms, trouble breathing and seizures.

Influenza virus infection Overview

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    Medical problem:

    Flu (influenza virus infection and symptoms).

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    Symptoms and signs:

    Cough, dizziness, fever, headache, nausea, pains, runny nose, sore throat, vomiting and aches.

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    Complications:

    Ear infection, lung infection, Seizures.

Brand Names

Neuraminidase inhibitors (RX)

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