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Neuraminidase inhibitors (RX) for treatment of Flu in Children with Cystic Fibrosis with Flu

  • Unclear

    Bottom Line

  • Treatment with Neuraminidase inhibitors (e.g. zanamivir, oseltamivir). No studies conducted, and therefore no data exists on benefits. Seems safe for Oseltamivir. Mild known side effects, including vomiting. Zanamivir may evoke asthma attacks and is risky for children with Cystic Fibrosis.



Do not use this treatment:

No data exists on the benefits. Side effects seem mild for Oseltamivir, while Zanamivir is risky for CF patients.

Doctors Say That

Works best if taken within 2 days of having flu symptoms, and should be taken for 5 consecutive days.

About Neuraminidase inhibitors (RX)

For example: Oseltamivir (Tamiflu), Zanamivir (Relenza)

  • Target Population:

    Children with Cystic Fibrosis, 2 to 16 years old

  • Dosage:

    Varies according to age, weight and treatment. Oseltamivir usually 2 mg/kg, twice-daily, for 5 days. Zanamivir usually 10 mg, twice-daily, for 5 days.

  • Goal:

    Treatment of Influenza infection, symptoms and complications

Research Summary

  • Not tested
  • Clinical Studies
  • Children Tested
  • Unclear
  • Benefits:

    Unknown. No valid clinical trials.

  • Dangerous
  • Risks:

    Common side effects include vomiting, diarrhea, nausea, headache, nosebleeds and trouble sleeping. Rare side effects may include psychiatric symptoms, trouble breathing and seizures. Zanamivir is risky for children with Cystic Fibrosis, as it may lead to Asthma attacks.

Influenza virus infection Overview

  • Medical problem:

    Flu (influenza virus infection and symptoms).

  • Symptoms and signs:

    Cough, dizziness, fever, headache, nausea, pains, runny nose, sore throat, vomiting and aches.

  • Complications:

    Ear infection, lung infection, Seizures.

Other Treatments

Brand Names

Neuraminidase inhibitors (RX)

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Neuraminidase inhibitors (NAIs) are a class of drugs which block the neuraminidase enzyme. They are commonly used as antiviral drugs because they block the function of viral neuraminidases of the influenza virus, by preventing its reproduction by budding from the host cell. Oseltamivir (Tamiflu) a prodrug, Zanamivir (Relenza), Laninamivir (Inavir), and Peramivir belong to this class. (source)
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