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Amantadine and Rimantadine
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(RX)
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  • RX
for
prevention
  • Prevention and Treatment
  • Prevention
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Flu
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Amantadine and Rimantadine (RX) for prevention of Flu in healthy Adults

  • Mixed

    Bottom Line

  • Prevention of influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 21 studies conducted, with 25,783 adults. Prevents 25% of influenza-like-illness in and over 60% of confirmed flu type A infections during influenza A epidemic outbreaks. Unknown impact in flu complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

    • EVIDENCE | WELL TESTED
    • EFFECTIVENESS | MILD BENEFITS
    • SAFETY | DANGEROUS

Recommendations

Avoid this treatment:

Consider Neuraminidase inhibitors instead (Amantadine and Rimantadine are less safe, and discontinued by the manufacturer in the USA).

Doctors Say That

This treatment makes sense only during an influenza A epidemic, and if other possibilities (including Neuraminidase inhibitors) fail.

About Amantadine and Rimantadine (RX)

Antiviral drugs (Symmetrel and Flumadine)

  • Target Population:

    healthy Adults, 16 to 65 years old

  • Dosage:

    Amantadine or Rimantadine, usually 100 mg orally, twice a day

  • Goal:

    Prevention of Influenza A infection, symptoms and complications

Research Summary

  • Well tested
  • 21 Clinical Studies
  • 25,783 Adults Tested
  • Mild benefits
  • Benefits:

    Preventing almost 2 out of 3 influenza A infections, and 1 out of 4 influenza-like-illness (including similar symptoms due to other viruses and causes) in Adults, which is mainly helpful during known outbreaks of Influenza A epidemic. Unknown impact on complications.

  • Dangerous
  • Risks:

    Common side effects include nausea, loss of appetite, constipation or diarrhea, and upset stomach for both drugs, while for Amantadine can also have serious effects on the nervous system, leading to concentration difficulties and psychiatric symptoms.

Influenza A virus infection Overview

  • Medical problem:

    Flu (influenza A virus infection and symptoms).

  • Symptoms and signs:

    Cough, dizziness, fever, headache, nausea, pains, runny nose, sore throat, vomiting and aches.

  • Complications:

    Ear infection, lung infection, Seizures.

Other Treatments

Brand Names

Amantadine and Rimantadine (RX)

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Amantadine (trade name Symmetrel, by Endo Pharmaceuticals) is a drug that has U.S. Food and Drug Administration approval for use both as an antiviral and an antiparkinsonian drug. Rimantadine (INN, sold under the trade name Flumadine) is an orally administered antiviral drug used to treat, and in rare cases prevent, influenza virus A infection. Both rimantadine and Amantadine are derivates of adamantane. (source)
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