Prevention of influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 21 studies conducted, with 25,783 adults. Prevents 25% of influenza-like-illness in and over 60% of confirmed flu type A infections during influenza A epidemic outbreaks. Unknown impact in flu complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.
Avoid this treatment:
Consider Neuraminidase inhibitors instead (Amantadine and Rimantadine are less safe, and discontinued by the manufacturer in the USA).
This treatment makes sense only during an influenza A epidemic, and if other possibilities (including Neuraminidase inhibitors) fail.
Antiviral drugs (Symmetrel and Flumadine)
healthy Adults, 16 to 65 years old
Amantadine or Rimantadine, usually 100 mg orally, twice a day
Prevention of Influenza A infection, symptoms and complications
Preventing almost 2 out of 3 influenza A infections, and 1 out of 4 influenza-like-illness (including similar symptoms due to other viruses and causes) in Adults, which is mainly helpful during known outbreaks of Influenza A epidemic. Unknown impact on complications.
Common side effects include nausea, loss of appetite, constipation or diarrhea, and upset stomach for both drugs, while for Amantadine can also have serious effects on the nervous system, leading to concentration difficulties and psychiatric symptoms.
Flu (influenza A virus infection and symptoms).
Symptoms and signs:
Cough, dizziness, fever, headache, nausea, pains, runny nose, sore throat, vomiting and aches.
Ear infection, lung infection, Seizures.
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Amantadine and Rimantadine
Amantadine (trade name Symmetrel, by Endo Pharmaceuticals) is a drug that has U.S. Food and Drug Administration approval for use both as an antiviral and an antiparkinsonian drug. Rimantadine (INN, sold under the trade name Flumadine) is an orally administered antiviral drug used to treat, and in rare cases prevent, influenza virus A infection. Both rimantadine and Amantadine are derivates of adamantane. (source)
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