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Amantadine and Rimantadine (RX) for prevention of Flu in healthy Adults

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    Bottom Line

  • Prevention of influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 21 studies conducted, with 25,783 adults. Prevents 25% of influenza-like-illness in and over 60% of confirmed flu type A infections during influenza A epidemic outbreaks. Unknown impact in flu complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

    • -  Evidence icon EVIDENCE | WELL TESTED
    • -  Effectiveness icon EFFECTIVENESS | MILD BENEFITS
    • -  Safety Circle icon SAFETY | DANGEROUS -  Tooltip icon Consult a Doctor


Avoid this treatment:

Consider Neuraminidase inhibitors instead (Amantadine and Rimantadine are less safe, and discontinued by the manufacturer in the USA).

Doctors Say That -  Tooltip icon

This treatment makes sense only during an influenza A epidemic, and if other possibilities (including Neuraminidase inhibitors) fail.

About Amantadine and Rimantadine (RX)

Antiviral drugs (Symmetrel and Flumadine)

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    Target Population:

    healthy Adults, 16 to 65 years old

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    Amantadine or Rimantadine, usually 100 mg orally, twice a day

  • - Goal icon


    Prevention of Influenza A infection, symptoms and complications

Research Summary

  • - Green Pages icon Well tested
  • 21 Clinical Studies
  • 25,783 - Tooltip icon Adults Tested
  • Mild benefits
  • Benefits:

    Preventing almost 2 out of 3 influenza A infections, and 1 out of 4 influenza-like-illness (including similar symptoms due to other viruses and causes) in Adults, which is mainly helpful during known outbreaks of Influenza A epidemic. Unknown impact on complications.

  • - Safety icon Dangerous
  • Risks:

    Common side effects include nausea, loss of appetite, constipation or diarrhea, and upset stomach for both drugs, while for Amantadine can also have serious effects on the nervous system, leading to concentration difficulties and psychiatric symptoms.

Influenza A virus infection Overview

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    Medical problem:

    Flu (influenza A virus infection and symptoms).

  • - Sumptoms icon

    Symptoms and signs:

    Cough, dizziness, fever, headache, nausea, pains, runny nose, sore throat, vomiting and aches.

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    Ear infection, lung infection, Seizures.

Other Treatments

Brand Names

Amantadine and Rimantadine (RX)

Additional Information

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