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Amantadine and Rimantadine
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Amantadine and Rimantadine (RX) for treatment of Flu in Adults with Flu

  • Mixed

    Bottom Line

  • Treatment of Influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 13 studies conducted, with 1,151 adults. Shortened the duration of fever by about one day. Unknown impact on complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

    • EVIDENCE | REASONABLY TESTED
    • EFFECTIVENESS | MILD BENEFITS for fever
    • SAFETY | MILD RISKS

Recommendations

Avoid this treatment:

Proven benefits include only avoiding one day of fever, while side effects are often irritating for both treatments, and are pretty dangerous for Amantadine.

Doctors Say That

Sometimes no treatment is the best treatment…

About Amantadine and Rimantadine (RX)

Antiviral drugs (Symmetrel and Flumadine)

  • Target Population:

    Adults with Flu, 16 to 65 years old

  • Dosage:

    Amantadine or Rimantadine, usually 100 mg orally, twice a day for 7 days

  • Goal:

    Treatment of Influenza A infection, symptoms and complications

Research Summary

  • Reasonably tested
  • 13 Clinical Studies
  • 1,151 Adults Tested
  • Mild benefits
  • Benefits:

    Shortens the duration of fever by about one day. Does not interrupt transmission. Unknown impact on complications.

  • Mild risks
  • Risks:

    Common side effects include nausea, loss of appetite, constipation or diarrhea, and upset stomach for both drugs, while for Amantadine can also have serious effects on the nervous system, leading to concentration difficulties and psychiatric symptoms.

Influenza A virus infection Overview

  • Medical problem:

    Flu (influenza A virus infection and symptoms).

  • Symptoms and signs:

    Cough, dizziness, fever, headache, nausea, pains, runny nose, sore throat, vomiting and aches.

  • Complications:

    Ear infection, lung infection, Seizures.

Other Treatments

Brand Names

Amantadine and Rimantadine (RX)

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Amantadine (trade name Symmetrel, by Endo Pharmaceuticals) is a drug that has U.S. Food and Drug Administration approval for use both as an antiviral and an antiparkinsonian drug. Rimantadine (INN, sold under the trade name Flumadine) is an orally administered antiviral drug used to treat, and in rare cases prevent, influenza virus A infection. Both rimantadine and Amantadine are derivates of adamantane. (source)
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