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Amantadine and Rimantadine
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Amantadine and Rimantadine (RX) for prevention of Flu in healthy Children

  • Mixed

    Bottom Line

  • Prevention of influenza A with Amantadine and Rimantadine. 5 studies conducted, with 1,007 children. Amantadine prevents 5.88% of confirmed flu type A infections during influenza A epidemic outbreaks, while Rimantadine is ineffective. The impact of both on complications is unclear. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

    • EVIDENCE | NEEDS MORE TESTING
    • EFFECTIVENESS | MILD BENEFITS
    • SAFETY | DANGEROUS

Recommendations

Avoid this treatment:

Try Neuraminidase inhibitors instead (they are as effective, but safer).

About Amantadine and Rimantadine (RX)

Antiviral drugs (Symmetrel and Flumadine)

  • Target Population:

    healthy Children, 2 to 16 years old

  • Dosage:

    Amantadine or Rimantadine, usually 100 mg for 10 years or older children orally twice a day, or 75 mg or less (according to prescription) for 1-9 years old children, orally twice a day.

  • Goal:

    Prevention of Influenza A infection, symptoms and complications

Research Summary

  • Needs more testing
  • 5 Clinical Studies
  • 1,007 Children Tested
  • Mild benefits
  • Benefits:

    Amantadine prevents 1 case of influenza A infection when the vaccine is given daily to 12 children (for a period of 14 to 18 weeks). Rimantadine is ineffective for prevention of influenza A. The impact on complications for both treatments is unknown.

  • Dangerous
  • Risks:

    Common side effects include nausea, loss of appetite, constipation or diarrhea, and upset stomach for both drugs, while for Amantadine can also have serious effects on the nervous system, leading to concentration difficulties and psychiatric symptoms.

Influenza A virus infection Overview

  • Medical problem:

    Flu (influenza A virus infection and symptoms).

  • Symptoms and signs:

    Cough, dizziness, fever, headache, nausea, pains, runny nose, sore throat, vomiting and aches.

  • Complications:

    Ear infection, lung infection, Seizures.

Brand Names

Amantadine and Rimantadine (RX)

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Amantadine (trade name Symmetrel, by Endo Pharmaceuticals) is a drug that has U.S. Food and Drug Administration approval for use both as an antiviral and an antiparkinsonian drug. Rimantadine (INN, sold under the trade name Flumadine) is an orally administered antiviral drug used to treat, and in rare cases prevent, influenza virus A infection. Both rimantadine and Amantadine are derivates of adamantane. (source)
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