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Amantadine and Rimantadine
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Amantadine and Rimantadine (RX) for treatment of Flu in Children with Flu

  • Mixed

    Bottom Line

  • Treatment of Influenza A with Amantadine and Rimantadine. 3 studies conducted, with 382 children. Reduces the fever on the 3rd day of treatment for 1 in 6 treated children, and ineffective for other symptoms. Unknown impact on complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

    • EVIDENCE | NEEDS MORE TESTING
    • EFFECTIVENESS | NEGLIGIBLE BENEFITS
    • SAFETY | DANGEROUS

Recommendations

Avoid this treatment:

Proven benefits include only reduced fever, while side effects are often irritating for both treatments, and are pretty dangerous for Amantadine. Consider Neuraminidase inhibitors instead (they are as effective, but safer).

About Amantadine and Rimantadine (RX)

Antiviral drugs (Symmetrel and Flumadine)

  • Target Population:

    Children with Flu, 2 to 16 years old

  • Dosage:

    Amantadine or Rimantadine, usually 100 mg for 10 years or older children orally twice a day, or 75 mg or less (according to prescription) for 1-9 years old children, orally twice a day.

  • Goal:

    Treatment of Influenza A infection, symptoms and complications

Research Summary

  • Needs more testing
  • 3 Clinical Studies
  • 382 Children Tested
  • Negligible benefits
  • Benefits:

    Reduces the fever on the 3rd day of treatment, but ineffective for other symptoms. Unknown impact on complications.

  • Dangerous
  • Risks:

    Common side effects include nausea, loss of appetite, constipation or diarrhea, and upset stomach for both drugs, while for Amantadine can also have serious effects on the nervous system, leading to concentration difficulties and psychiatric symptoms.

Influenza A virus infection Overview

  • Medical problem:

    Flu (influenza A virus infection and symptoms).

  • Symptoms and signs:

    Cough, dizziness, fever, headache, nausea, pains, runny nose, sore throat, vomiting and aches.

  • Complications:

    Ear infection, lung infection, Seizures.

Other Treatments

Brand Names

Amantadine and Rimantadine (RX)

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Amantadine (trade name Symmetrel, by Endo Pharmaceuticals) is a drug that has U.S. Food and Drug Administration approval for use both as an antiviral and an antiparkinsonian drug. Rimantadine (INN, sold under the trade name Flumadine) is an orally administered antiviral drug used to treat, and in rare cases prevent, influenza virus A infection. Both rimantadine and Amantadine are derivates of adamantane. (source)
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