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Amantadine and Rimantadine
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(RX)
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for
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  • Prevention and Treatment
  • Prevention
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Flu
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Seniors
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Amantadine and Rimantadine (RX) for prevention of Flu in healthy Seniors

  • Damaging

    Bottom Line

  • Prevention of influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 4 studies conducted, with 838 seniors. Ineffective in prevention of flu type A infections. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

    • EVIDENCE | NEEDS MORE TESTING
    • EFFECTIVENESS | INEFFECTIVE
    • SAFETY | DANGEROUS

Recommendations

Avoid this treatment:

It is ineffective, unsafe, and discontinued by the manufacturer in the USA.

About Amantadine and Rimantadine (RX)

Antiviral drugs (Symmetrel and Flumadine)

  • Target Population:

    healthy Seniors, 65 year old and above

  • Dosage:

    Amantadine or Rimantadine, usually 100 mg orally, once a day

  • Goal:

    Prevention of Influenza A infection, symptoms and complications

Research Summary

  • Needs more testing
  • 4 Clinical Studies
  • 838 Seniors Tested
  • Ineffective
  • Benefits:

    Ineffective. Does not prevent flu symptoms. Does not prevent complications.

  • Dangerous
  • Risks:

    Common side effects include nausea, loss of appetite, constipation or diarrhea, and upset stomach and rash for both drugs, while for Amantadine can also have serious effects on the nervous system, leading to concentration difficulties and psychiatric symptoms.

Influenza A virus infection Overview

  • Medical problem:

    Flu (influenza A virus infection and symptoms).

  • Symptoms and signs:

    Cough, dizziness, fever, headache, nausea, pains, runny nose, sore throat, vomiting and aches.

  • Complications:

    Ear infection, lung infection, Seizures.

Brand Names

Amantadine and Rimantadine (RX)

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Amantadine (trade name Symmetrel, by Endo Pharmaceuticals) is a drug that has U.S. Food and Drug Administration approval for use both as an antiviral and an antiparkinsonian drug. Rimantadine (INN, sold under the trade name Flumadine) is an orally administered antiviral drug used to treat, and in rare cases prevent, influenza virus A infection. Both rimantadine and Amantadine are derivates of adamantane. (source)
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