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Amantadine and Rimantadine (RX) for prevention of Flu in healthy Seniors

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    Damaging

    Bottom Line

  • Prevention of influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 4 studies conducted, with 838 seniors. Ineffective in prevention of flu type A infections. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

    • Curefacts.com -  Evidence icon EVIDENCE | NEEDS MORE TESTING
    • Curefacts.com -  Effectiveness icon EFFECTIVENESS | INEFFECTIVE
    • Curefacts.com -  Safety Circle icon SAFETY | DANGEROUS

Recommendations

Avoid this treatment:

It is ineffective, unsafe, and discontinued by the manufacturer in the USA.

About Amantadine and Rimantadine (RX)

Antiviral drugs (Symmetrel and Flumadine)

  • Curefacts.com - Population icon

    Target Population:

    healthy Seniors, 65 year old and above

  • Curefacts.com - Dosage icon

    Dosage:

    Amantadine or Rimantadine, usually 100 mg orally, once a day

  • Curefacts.com - Goal icon

    Goal:

    Prevention of Influenza A infection, symptoms and complications

Research Summary

  • Curefacts.com - Green Pages icon Needs more testing
  • 4 Clinical Studies
  • 838 Curefacts.com - Tooltip icon Seniors Tested
  • Ineffective
  • Benefits:

    Ineffective. Does not prevent flu symptoms. Does not prevent complications.

  • Curefacts.com - Safety icon Dangerous
  • Risks:

    Common side effects include nausea, loss of appetite, constipation or diarrhea, and upset stomach and rash for both drugs, while for Amantadine can also have serious effects on the nervous system, leading to concentration difficulties and psychiatric symptoms.

Influenza A virus infection Overview

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    Medical problem:

    Flu (influenza A virus infection and symptoms).

  • Curefacts.com - Sumptoms icon

    Symptoms and signs:

    Cough, dizziness, fever, headache, nausea, pains, runny nose, sore throat, vomiting and aches.

  • Curefacts.com - Complications icon

    Complications:

    Ear infection, lung infection, Seizures.

Brand Names

Amantadine and Rimantadine (RX)

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