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Amantadine and Rimantadine (RX) for treatment of Flu in Seniors with Flu

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    Unclear

    Bottom Line

  • Treatment of Influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. No valid studies conducted. Therefore, no data exists on benefits. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

    • Curefacts.com -  Evidence icon EVIDENCE | NOT TESTED
    • Curefacts.com -  Effectiveness icon EFFECTIVENESS | UNCLEAR
    • Curefacts.com -  Safety Circle icon SAFETY | DANGEROUS

Recommendations

Avoid this treatment:

No data exists on benefits for seniors, and these treatments are possibly dangerous and were discontinued by the manufacturer in the USA.

About Amantadine and Rimantadine (RX)

Antiviral drugs (Symmetrel and Flumadine)

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    Target Population:

    Seniors with Flu, 65 year old and above

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    Dosage:

    Amantadine or Rimantadine, usually 100 mg orally, twice a day for 7 days

  • Curefacts.com - Goal icon

    Goal:

    Treatment of Influenza A infection, symptoms and complications

Research Summary

  • Curefacts.com - Green Pages icon Not tested
  • Clinical Studies
  • Curefacts.com - Tooltip icon Seniors Tested
  • Unclear
  • Benefits:

    Unknown. No valid clinical trials.

  • Curefacts.com - Safety icon Dangerous
  • Risks:

    Common side effects include nausea, loss of appetite, constipation or diarrhea, and upset stomach and rash for both drugs, while for Amantadine can also have serious effects on the nervous system, leading to concentration difficulties and psychiatric symptoms.

Influenza A virus infection Overview

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    Medical problem:

    Flu (influenza A virus infection and symptoms).

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    Symptoms and signs:

    Cough, dizziness, fever, headache, nausea, pains, runny nose, sore throat, vomiting and aches.

  • Curefacts.com - Complications icon

    Complications:

    Ear infection, lung infection, Seizures.

Other Treatments

Brand Names

Amantadine and Rimantadine (RX)

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Additional Information

Amantadine and Rimantadine

Amantadine (trade name Symmetrel, by Endo Pharmaceuticals) is a drug that has U.S. Food and Drug Administration approval for use both as an antiviral and an antiparkinsonian drug. Rimantadine (INN, sold under the trade name Flumadine) is an orally administered antiviral drug used to treat, and in rare cases prevent, influenza virus A infection. Both rimantadine and Amantadine are derivates of adamantane. (source)

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