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Flu Nasal Aerosol
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Flu Nasal Aerosol (vaccine) for prevention of Flu in Children with Cystic Fibrosis

  • Unclear

    Bottom Line

  • Flu nose spray vaccine with “live” (weakened) viruses. 2 studies conducted, with 60 children. Unclear benefits. Strong side effects. Known serious harms.

    • EVIDENCE | POORLY TESTED
    • EFFECTIVENESS | UNCLEAR
    • SAFETY | DANGEROUS

Recommendations

Do not use this treatment

No data exists on benefits. Side effects are strong and very frequent. High risk potential, due to known cases of serious harms in healthy children.

About Flu Nasal Aerosol (vaccine)

Flu nose spray vaccine with “live” (weakened) viruses

  • Target Population:

    Children with Cystic Fibrosis, 2 to 16 years old

  • Dosage:

    Seasonal vaccine (once a year). 0.2 mL. One dose or (sometimes, for children 2-8 years old) two doses at least 1 month apart.

  • Goal:

    Prevention of Influenza infection, symptoms and complications.

Research Summary

  • Poorly tested
  • 2 Clinical Studies
  • 60 Children Tested
  • Unclear
  • Benefits:

    Unclear. It does evoke immune system response, but it is not clear if this response brings actual benefits (prevention of flu symptoms and flu complications).

  • Dangerous
  • Risks:

    Unclear. More research needed. The studies resulted high frequency of side effects, but none were life threatening or persistent. Irritating side effects include: runny nose, cough, headache, fever, nausea, diarrhea, muscle aches. In healthy children there are known cases of serious harms, such as febrile convulsions, cataplexy and narcolepsy.

Influenza virus infection Overview

  • Medical problem:

    Flu (influenza virus infection and symptoms).

  • Symptoms and signs:

    Cough, dizziness, fever, headache, nausea, pains, runny nose, sore throat, vomiting and aches.

  • Complications:

    Ear infection, lung infection, Seizures.

Other Treatments

Brand Names

Flu Nose Spray (vaccine)

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Live attenuated influenza vaccine (LAIV) is a type of influenza vaccine in the form of a nasal spray. It is an attenuated vaccine, unlike most influenza vaccines, which are inactivated vaccines. LAIV is administered intranasally, while inactivated vaccines are administered by intramuscular injection. Both live attenuated and inactivated vaccines are typically trivalent, since they contain material from three different influenza virus. LAIV is sold under the trade name FluMist in the United States and Canada. (source)
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