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Antihistamine and decongestant combination (OTC) for treatment of Common Cold in Children with cold

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    Insignificant

    Bottom Line

  • Treatment with antihistamine and decongestant combination (e.g. triprolidine and pseudoephedrine). 12 valid studies conducted, with 1,239 adults and children. Improves general feeling and may slightly reduce sneezing, cough, runny nose and stuffy nose . Side effects seem minor, and include dry mouth and insomnia.

    • Curefacts.com -  Evidence icon EVIDENCE | REASONABLY TESTED
    • Curefacts.com -  Effectiveness icon EFFECTIVENESS | MILD BENEFITS for cough, general discomfort, runny nose, sneezing and stuffy nose
    • Curefacts.com -  Safety Circle icon SAFETY | PROBABLY SAFE
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Recommendations

Look for alternatives to this treatment:

It has very little measurable impact, and usually brings only temporary and quite insignificant relief. Side effects seem minor.

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Note that while infections with various strains of Corona viruses are responsible for most cases of common cold, the new corona virus strain, SARS-CoV-2, leads to an entirely different coronavirus infectious disease, COVID-19. The research of treatments for COVID-19 is still pre mature and not based on solid evidence. Therefore, at this stage, we can only speculate that effective treatments for common cold (and related Corona virus strains) may prove effective for Corona disease 2019 (COVID-19) and the related SARS-CoV-2 strain. Please don't count on it.

About Antihistamine and decongestant combination (OTC)

For example: a combination of Triprolidine and Pseudoephedrine

  • Curefacts.com - Population icon

    Target Population:

    Children with cold, 2 to 16 years old

  • Curefacts.com - Dosage icon

    Dosage:

    Varies according to combination, age and weight.

  • Curefacts.com - Goal icon

    Goal:

    Treatment of Common Cold symptoms

Research Summary

  • Curefacts.com - Green Pages icon Reasonably tested
  • 12 Clinical Studies
  • 1,239 Curefacts.com - Tooltip icon Children Tested
  • Mild benefits
  • Benefits:

    Improves general feeling and may slightly reduce sneezing, cough, runny nose and blockage of the nose. Ineffective for children younger than 5 years old.

  • Curefacts.com - Safety icon Probably safe
  • Risks:

    Minor reported side effects include dry mouth and insomnia.

Common Cold Overview

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    Medical problem:

    Common Cold (symptoms caused by viral infection of the upper respiratory system).

  • Curefacts.com - Sumptoms icon

    Symptoms and signs:

    Cough, general discomfort, headache, runny nose, sneezing, sore throat, stuffy nose and weakness.

  • Curefacts.com - Complications icon

    Complications:

    Bacterial infections: lung infection, middle ear infection, strep throat, sinus infection.

Brand Names

Antihistamine and decongestant combination (OTC)

  • Alavert
  • Allerfrim
  • Allerphed
  • Altafed
  • Aphedrid
  • A-Phedrin
  • Aprodine
  • Biofed-PE
  • Claritin-D
  • Conex
  • Drixoral
  • Genac
  • Histafed
  • Hist-PSE
  • Loratadine-D
  • Pediatex TD
  • Trip-PSE
  • Vi-Sudo
  • Zymine-D

Additional Information

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