Insignificant
Bottom Line
Treatment with antihistamine and decongestant combination (e.g. triprolidine and pseudoephedrine). 12 valid studies conducted, with 1,239 individuals. Improves general feeling and may slightly reduce sneezing, cough, runny nose and stuffy nose . Side effects seem minor, and include dry mouth, insomnia and constipation.
EVIDENCE | REASONABLY TESTED
EFFECTIVENESS | MILD BENEFITS for cough, general discomfort, runny nose, sneezing and stuffy nose
SAFETY | PROBABLY SAFE
Do not use this treatment:
It has very little measurable impact, and usually brings only temporary and quite insignificant relief. Side effects seem minor.
If you suffer from high blood pressure avoid this treatment: decongestants can increase your blood pressure even further, and put you at risk.
For example: a combination of Triprolidine and Pseudoephedrine
Target Population:
Adults with cold, 16 to 65 years old
Dosage:
Varies according to combination.
Goal:
Treatment of Common Cold symptoms
Reasonably tested
Adults Tested
Benefits:
Improves general feeling and may slightly reduce sneezing, cough, runny nose and blockage of the nose.
Probably safe
Risks:
Minor reported side effects include dry mouth, insomnia and constipation. Decongestants may increase blood pressure.
Medical problem:
Common Cold (symptoms caused by viral infection of the upper respiratory system).
Symptoms and signs:
Cough, general discomfort, headache, runny nose, sneezing, sore throat, stuffy nose and weakness.
Complications:
Bacterial infections: lung infection, middle ear infection, strep throat, sinus infection.
Antihistamine and decongestant combination (OTC)
Additional Information
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Antihistamines are drugs which treat allergic rhinitis and other allergies. As an alternative to taking an antihistamine, people who suffer from allergies can instead avoid the substance which irritates them. Antihistamines are usually for short-term treatment. A decongestants, or nasal decongestant, is a type of pharmaceutical drug that is used to relieve nasal congestion in the upper respiratory tract. The active ingredient in most decongestants is either pseudoephedrine or phenylephrine. (source)
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