Treatment with Antihistamine and Analgesic OTC combination. 3 valid studies conducted, with 1,508 participants. Reduces fever, pain and perhaps sneezing, and improves general feeling (but does not seem to reduce cough, runny nose, and stuffy nose). Side effects seem minor, when sticking to recommended dosage.
Consider this treatment with caution, and only when sneezing:
Analgesics improve general feeling and reliefs discomfort caused by a cold (fever, pain). Antihistamines may slightly relief sneezing. Do not expect this treatment to reduce cough, stuffy nose and runny nose or to speed up recovery. Side effects seem minor. All in all - in most cases you'd better use only Paracetamol instead.
You should prefer combinations with Paracetamol, since they are safer than combinations with NSAIDs (e.g. Advil) . Using NSAIDs can cause severe damage, especially to adults with gastric-intestinal infections or hidden kidney disease, which are quite common.
Note that while infections with various strains of Corona viruses are responsible for most cases of common cold, the new corona virus strain, SARS-CoV-2, leads to an entirely different coronavirus infectious disease, COVID-19. The research of treatments for COVID-19 is still pre mature and not based on solid evidence. Therefore, at this stage, we can only speculate that effective treatments for common cold (and related Corona virus strains) may prove effective for Corona disease 2019 (COVID-19) and the related SARS-CoV-2 strain. Please don't count on it.
For example: Diphenhydramine Hydrochloride and Acetaminophen combination
Adults with cold, 16 to 65 years old
Varies according to combination. Stick to the directions on the package or as prescribed by your doctor.
Treatment of Common Cold symptoms
Reduces fever and pain and improves general feeling. May slightly reduce sneezing. Does not seem to improve cough, runny nose and stuffy nose.
Minor reported side effects vary according to combination (for example - dry mouth, drowsiness, constipation, nausea).
Common Cold (symptoms caused by viral infection of the upper respiratory system).
Symptoms and signs:
Cough, general discomfort, headache, runny nose, sneezing, sore throat, stuffy nose and weakness.
Bacterial infections: lung infection, middle ear infection, strep throat, sinus infection.
Antihistamine and analgesic combination (OTC)
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Antihistamines are drugs which treat allergic rhinitis and other allergies. As an alternative to taking an antihistamine, people who suffer from allergies can instead avoid the substance which irritates them. Antihistamines are usually for short-term treatment. An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain. Analgesic drugs act in various ways on the peripheral and central nervous systems. Analgesics include paracetamol (known in North America as acetaminophen or simply APAP), the nonsteroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, and opioid drugs such as morphine and oxycodone. (source)
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