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Amantadine and Rimantadine (RX) for treatment of flu in Adults with Flu

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    Bottom Line

  • Treatment of Influenza A with Amantadine and Rimantadine. This treatment has been replaced by neuraminidase inhibitors and is no longer used in the USA. 13 studies conducted, with 1,151 adults. Shortened the duration of fever by about one day. Unknown impact on complications. Both drugs have irritating stomach and gut effects, while Amantadine may also impair the nervous system and lead to psychiatric symptoms.

    • -  Evidence icon EVIDENCE | REASONABLY TESTED
    • -  Effectiveness icon EFFECTIVENESS | MILD BENEFITS for fever
    • -  Safety Circle icon SAFETY | MILD RISKS -  Tooltip icon Consult a Doctor


Avoid this treatment:

Proven benefits include only avoiding one day of fever, while side effects are often irritating for both treatments, and are pretty dangerous for Amantadine.

Doctors Say That -  Tooltip icon

Sometimes no treatment is the best treatment…

About Amantadine and Rimantadine (RX)

Antiviral drugs (Symmetrel and Flumadine)

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    Target Population:

    Adults with Flu, 16 to 65 years old

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    Amantadine or Rimantadine, usually 100 mg orally, twice a day for 7 days

  • - Goal icon


    Treatment of Influenza A infection, symptoms and complications

Research Summary

  • - Green Pages icon Reasonably tested
  • 13 Clinical Studies
  • 1,151 - Tooltip icon Adults Tested
  • Mild benefits
  • Benefits:

    Shortens the duration of fever by about one day. Does not interrupt transmission. Unknown impact on complications.

  • - Safety icon Mild risks
  • Risks:

    Common side effects include nausea, loss of appetite, constipation or diarrhea, and upset stomach for both drugs, while for Amantadine can also have serious effects on the nervous system, leading to concentration difficulties and psychiatric symptoms.

Influenza A virus infection Overview

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    Medical problem:

    Flu (influenza A virus infection and symptoms).

  • - Sumptoms icon

    Symptoms and signs:

    Cough, dizziness, fever, headache, nausea, pains, runny nose, sore throat, vomiting and aches.

  • - Complications icon


    Ear infection, lung infection, Seizures.

Other Treatments

Brand Names

Amantadine and Rimantadine (RX)

Additional Information

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