Unclear
Bottom Line
Flu nose spray vaccine with “live” (weakened) viruses. 2 studies conducted, with 60 children. Unclear benefits. Strong side effects. Known serious harms.
EVIDENCE | POORLY TESTED
EFFECTIVENESS | UNCLEAR
SAFETY | DANGEROUS
Do not use this treatment
No data exists on benefits. Side effects are strong and very frequent. High risk potential, due to known cases of serious harms in healthy children.
Flu nose spray vaccine with “live” (weakened) viruses
Target Population:
Children with Cystic Fibrosis, 2 to 16 years old
Dosage:
Seasonal vaccine (once a year). 0.2 mL. One dose or (sometimes, for children 2-8 years old) two doses at least 1 month apart.
Goal:
Prevention of Influenza infection, symptoms and complications.
Poorly tested
Children Tested
Benefits:
Unclear. It does evoke immune system response, but it is not clear if this response brings actual benefits (prevention of flu symptoms and flu complications).
Dangerous
Risks:
Unclear. More research needed. The studies resulted high frequency of side effects, but none were life threatening or persistent. Irritating side effects include: runny nose, cough, headache, fever, nausea, diarrhea, muscle aches. In healthy children there are known cases of serious harms, such as febrile convulsions, cataplexy and narcolepsy.
Medical problem:
Flu (influenza virus infection and symptoms).
Symptoms and signs:
Cough, dizziness, fever, headache, nausea, pains, runny nose, sore throat, vomiting and aches.
Complications:
Ear infection, lung infection, Seizures.
Additional Information
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Flu Nasal Aerosol
Live attenuated influenza vaccine (LAIV) is a type of influenza vaccine in the form of a nasal spray. It is an attenuated vaccine, unlike most influenza vaccines, which are inactivated vaccines. LAIV is administered intranasally, while inactivated vaccines are administered by intramuscular injection. Both live attenuated and inactivated vaccines are typically trivalent, since they contain material from three different influenza virus. LAIV is sold under the trade name FluMist in the United States and Canada. (source)
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